EFFECT OF WATER STRUCTURE ON POLY-ε-BENZYLOXYCARBONYL-L-LYSINE MONOLAYERS

Polyethylene glycol–poly(ε-benzyloxycarbonyl-l-lysine)-conjugated VEGF siRNA for antiangiogenic gene therapy in hepatocellular carcinoma

A polyethylene glycol-poly(ε-benzyloxycarbonyl-l-lysine) (PEG-SS-PLL) block copolymer based on a disulfide-linked, novel biodegradable catiomer bearing a PEG-sheddable shell was developed to avoid "PEG dilemma" in nanoparticle intracellular tracking of PEG-PLL where PEG was nondegradable. However, PEG-SS-PLL catiomers have not been used to deliver small interfering VEGF RNA (siVEGF) in antiangi...

Efficacy of ε-Poly-L-lysine as an Antibacterial Additive for Platelets Stored at Room Temperature

Antimicrobial effect of medical adhesive composed of aldehyded dextran and ε-Poly(L-Lysine).

Infection of surgical wounds is a severe problem. Conventional tissue reattachment methods have limits of incomplete sealing and high susceptibility to infection. Medical adhesives have several advantages over traditional tissue reattachment techniques, but still have drawbacks, such as the probability of infection, low adhesive strength, and high cytotoxicity. Recently, a new medical adhesive ...

The effect of poly-L-lysine structure on the pH response of polygalacturonic acid-based multilayers.

The effect of poly-L-lysine (PLL) molecular weight and structure on pH stability of polygalacturonic acid (PGaLA)-based multilayer films is studied over a pH cycle 7.0-1.6-7.0. The multilayer assembled with the lowest molecular weight PLL (1 kDa) showed the largest pH response. Only 12% of the mass remained and a preferential loss of PLL was observed. Extensive structural reorganisation of the ...

Promotion effect by ε-poly-L-lysine on the enzymatic reaction of glucose oxidase with ferricyanide ion as an oxidant.

An enzymatic reaction rate of glucose oxidase (GOD) using ferricyanide ion ([Fe(CN)(6)](3-)) as an oxidant significantly increased by the addition of ε-poly-L-lysine (ε-PL). The bimolecular rate constant between GOD and [Fe(CN)(6)](3-) in the presence of ε-PL reached about 10000-fold relative to what it was measured without the ε-PL, and the Michaelis constant decreased. The reaction rate reach...